| % File src/library/datasets/man/Indometh.Rd |
| % Part of the R package, https://www.R-project.org |
| % Copyright 1995-2011 R Core Team |
| % Distributed under GPL 2 or later |
| |
| \name{Indometh} |
| \docType{data} |
| \alias{Indometh} |
| \title{Pharmacokinetics of Indomethacin} |
| \description{ |
| The \code{Indometh} data frame has 66 rows and 3 columns of data on |
| the pharmacokinetics of indometacin (or, older spelling, |
| \sQuote{indomethacin}). |
| } |
| \usage{Indometh} |
| \format{ |
| An object of class |
| \code{c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame")} |
| containing the following columns: |
| \describe{ |
| \item{Subject}{ |
| an ordered factor with containing the subject codes. The |
| ordering is according to increasing maximum response. |
| } |
| \item{time}{ |
| a numeric vector of times at which blood samples were drawn (hr). |
| } |
| \item{conc}{ |
| a numeric vector of plasma concentrations of indometacin (mcg/ml). |
| } |
| } |
| } |
| \details{ |
| Each of the six subjects were given an intravenous injection of |
| indometacin. |
| |
| This dataset was originally part of package \code{nlme}, and that has |
| methods (including for \code{[}, \code{as.data.frame}, \code{plot} and |
| \code{print}) for its grouped-data classes. |
| } |
| \source{ |
| Kwan, Breault, Umbenhauer, McMahon and Duggan (1976) |
| Kinetics of Indomethacin absorption, elimination, and |
| enterohepatic circulation in man. |
| \emph{Journal of Pharmacokinetics and Biopharmaceutics} \bold{4}, |
| 255--280. |
| |
| Davidian, M. and Giltinan, D. M. (1995) |
| \emph{Nonlinear Models for Repeated Measurement Data}, |
| Chapman & Hall (section 5.2.4, p.\sspace{}129) |
| |
| Pinheiro, J. C. and Bates, D. M. (2000) \emph{Mixed-effects Models in |
| S and S-PLUS}, Springer. |
| } |
| \seealso{ |
| \code{\link{SSbiexp}} for models fitted to this dataset. |
| } |
| \keyword{datasets} |